Methanol → 4-(5-Methanesulfonyl-4-methyl-4h-[1,2,4]triazol-3-yl)-2-methoxy-pyridine

HRID 500546Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 500546
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[N:13]([CH3:14])[C:12](SC)=[N:11][N:10]=2)[CH:6]=[CH:5][N:4]=1.O[O:18][S:19]([O-:21])=O.[K+].S([O-])(O[O-])(=O)=O.[K+].[K+].[CH3:31]O>O>[CH3:31][S:19]([C:12]1[N:13]([CH3:14])[C:9]([C:7]2[CH:6]=[CH:5][N:4]=[C:3]([O:2][CH3:1])[CH:8]=2)=[N:10][N:11]=1)(=[O:21])=[O:18]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 10313463Potassium peroxymonosulphateHCID 23707502Potassium hydroxy sulfiteHCID 248517082-Methoxy-4-(4-methyl-5-methylsulfanyl-4h-[1,2,4]triazol-3-yl)-pyridine

Produkt 1

HCID 248518124-(5-Methanesulfonyl-4-methyl-4h-[1,2,4]triazol-3-yl)-2-methoxy-pyridineAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The title compound of example 25.1 (21.97 g, 92.97 mmol) was partially dissolved in methanol (500 mL) and OXONE® (potassium peroxomonosulfate compound, 114.3 g, 186.0 mmol) dissolved in water (500 mL) was added slowly. The reaction mixture stirred for 5 hours. The reaction was partially concentrated, poured into water and extracted with chloroform. The organic extracts were dried, filtered and concentrated to afford the title compound (22 g, 93%) as a white solid.

Aufarbeitung

  1. additionwas added slowly
  2. concentrationThe reaction was partially concentrated
  3. additionpoured into water
  4. extractionextracted with chloroform
  5. customThe organic extracts were dried
  6. filtrationfiltered
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d4a2b11b39e84215a1fcec443b3fdc39
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772235B2

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