HCID 24851818, Verbindung → HCID 24853176, Verbindung

HRID 500555Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 500555
C([O:8][C:9]1[CH:14]=[C:13]([C:15]2[N:19]([CH3:20])[C:18]([O:21][CH:22]([C:24]3[CH:28]=[C:27]([C:29]4[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[CH:30]=4)[O:26][N:25]=3)[CH3:23])=[N:17][N:16]=2)[CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>C(O)C.[Pd].ClCCl>[Cl:35][C:31]1[CH:30]=[C:29]([C:27]2[O:26][N:25]=[C:24]([CH:22]([O:21][C:18]3[N:19]([CH3:20])[C:15]([C:13]4[CH:12]=[CH:11][NH:10][C:9](=[O:8])[CH:14]=4)=[N:16][N:17]=3)[CH3:23])[CH:28]=2)[CH:34]=[CH:33][CH:32]=1

Komponenten

5

Edukt 1

HCID 24851818HCID 24851818, Verbindung

Produkt 1

HCID 24853176HCID 24853176, VerbindungAusbeute 38 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The title compound of example 35.1 (125 mg, 0.256 mmol) was stirred in ethanol (2 mL). Palladium on carbon (10%, 50 mg) was added and the reaction was stirred under hydrogen (balloon pressure) overnight. The reaction mixture was then diluted with dichloromethane and filtered to remove the palladium catalyst. The filtrate was concentrated, then chromatographed in 10% methanol in ethyl acetate to yield the desired product (38.5 mg, 38%).

Aufarbeitung

  1. filtrationfiltered
  2. customto remove the palladium catalyst
  3. concentrationThe filtrate was concentrated
  4. customchromatographed in 10% methanol in ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-a93f41b8699045c7999178beb229ede2
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772235B2

Notizen zur Reaktion

Wird geladen…