Hydrochloric Acid → 5-Methoxy-2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine

HRID 501088

Reaktionsgleichung

Reaktionsgleichung von HRID 501088
[CH3:1][O:2][C:3]1[N:8]=[C:7]2[NH:9][C:10](=[O:25])[N:11]([CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[C:6]2=[CH:5][CH:4]=1.Cl>CO.CCOCC>[CH3:1][O:2][C:3]1[N:8]=[C:7]2[NH:9][C:10](=[O:25])[N:11]([CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[C:6]2=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 222932805-Methoxy-2-oxo-1-(1-t-butoxycarbonylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine

Produkt 1

HCID 222931645-Methoxy-2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridineAusbeute 85,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

5-Methoxy-2-oxo-1-(1-t-butoxycarbonylpiperidin-4-yl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine (100 mg, 0.287 mmol) was dissolved in methanol (2.5 mL) and a solution of 2N hydrochloric acid in ether (3 mL) was added at room temperature. After 2 h, the volatiles were removed in vacuo, to give the title compound (61 mg). MS 249.1 (M+1).

Aufarbeitung

  1. customthe volatiles were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9fd44b6652ba419a94ac1b7779f24aab
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772224B2

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