Hydrochloric Acid → 2,4-Dimethoxybenzoic acid

HRID 501785

Reaktionsgleichung

Reaktionsgleichung von HRID 501785
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].C(Cl)(Cl)Cl.O.Cl>C(O)C.[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6212ChloroformHCID 137451Benzoic acid, 2,4-dimethoxy-, methyl ester

Produkt 1

HCID 70522,4-Dimethoxybenzoic acidAusbeute 91,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
32.5 °C

Versuchsvorschrift

53 g of methyl 2,4-dimethoxybenzoate was dissolved in 160 mL of ethanol, to which 104 mL of a 5M aqueous solution of sodium hydroxide was added, and this mixture was stirred for 2 hours at 25 to 40° C. Then, chloroform and water were added to the reaction mixture, which was adjusted to pH 2 with 6M hydrochloric acid, and then the organic phase was separated therefrom. After the resultant organic phase was washed with water and a saturated sodium chloride solution successively, the washed phase was dried over anhydrous magnesium sulfate, and the solvent was distilled out under reduced pressure to yield 45 g of 2,4-dimethoxybenzoic acid as white solid.

Aufarbeitung

  1. additionwas added
  2. customthe organic phase was separated
  3. washAfter the resultant organic phase was washed with water
  4. dry with materiala saturated sodium chloride solution successively, the washed phase was dried over anhydrous magnesium sulfate
  5. distillationthe solvent was distilled out under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e242f1be75104dde819827f3f1c9954d
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772285B2

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