Hydrochloric Acid → 4-Formyl-3-methoxybenzoic acid

HRID 501812

Reaktionsgleichung

Reaktionsgleichung von HRID 501812
[CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[CH:5][C:4]=1[O:13][CH3:14])=[O:2].O.Cl>CO.[OH-].[Na+]>[CH:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[O:13][CH3:14])=[O:2]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 10631650Methyl 4-formyl-3-methoxybenzoate

Produkt 1

HCID 189595314-Formyl-3-methoxybenzoic acidAusbeute 93,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

1.72 g of methyl 4-formyl-3-methoxybenzoate was dissolved in 8.6 mL of methanol, to which 2.6 mL of a 20% aqueous solution of sodium hydroxide was added at room temperature, and this solution was stirred for one hour at the same temperature. The reaction mixture, to which water was added, was adjusted to pH 2 with 6M hydrochloric acid, and resultant precipitate was filtered out therefrom and washed with water to yield 1.49 g of 4-formyl-3-methoxybenzoic acid as light yellow solid.

Aufarbeitung

  1. additionwas added at room temperature
  2. filtrationwas filtered out therefrom and
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-f300ada960e6404c8c73162ae3ae4977
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772285B2

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