Diethyl Ether → 2-Benzofuran-3-yl-ethanol

HRID 502503Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 502503
CO[C:3](=O)[CH2:4][C:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[O:7][CH:6]=1.[Li].CC[O:18]CC>>[CH:6]1[O:7][C:8]([CH:13]([OH:18])[CH3:12])=[C:9]2[CH:10]=[CH:11][CH:3]=[CH:4][C:5]=12

Komponenten

4

Edukt 3

HCID 3283Diethyl Ether2×HCID 3028194LithiumHCID 10976279Methyl Benzofuran-3-acetate

Produkt 1

HCID 684582562-Benzofuran-3-yl-ethanol

Versuchsvorschrift

A solution of benzofuran-3-yl-acetic acid methyl ester (4.0 g, 21 mmol) in 25 ml of ether was added dropwise at RT to a suspension of lithium alanate (1.61 g, 59.5 mmol) in 35 ml of ether, and stirring was then carried out for 30 minutes. Excess alanate was then hydrolysed with ethanol, the mixture was suction-filtered over Kieselguhr, and the solvent was removed in vacuo. The product was obtained in the form of a yellowish oil in a yield of 3.0 g (89%).

Aufarbeitung

  1. filtrationhydrolysed with ethanol, the mixture was suction-filtered over Kieselguhr
  2. customthe solvent was removed in vacuo
  3. customThe product was obtained in the form of a yellowish oil in a yield of 3.0 g (89%)

Quellen und Nachweise

ORD-Eintrag
ord-59bad4e82581494b96c626227b667a12
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776848B2

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