3-(Trifluoromethyl)phenyl isocyanate → 1-(4-Iodo-3-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea

HRID 502698Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 502698
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[CH3:9].[N:10]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=1)=[C:11]=[O:12].[N-]=C=O>C1C=CC=CC=1>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:11]([NH:10][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:20])([F:21])[F:22])[CH:14]=2)=[O:12])=[CH:4][C:3]=1[CH3:9]

Komponenten

5

Edukt 3

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 105034IsocyanateHCID 27342754-Iodo-3-methylaniline

Produkt 1

HCID 684617451-(4-Iodo-3-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a solution of 4-iodo-3-methylaniline (200 mg, 0.86 mmol) in benzene (5 mL) in a sealable tube was added 1-isocyanato-3-(trifluoromethyl)benzene (0.133 mL, 0.94 mL; “E” is an electrophilic group disussed in scheme 3, and here is an isocyanate). The tube was sealed and heated at 90° C. for 4 h. The mixture was allowed to cool to room temperature before filtering. The off white solid was washed with additional benzene (10 mL) and used without further purification.

Aufarbeitung

  1. customThe tube was sealed
  2. temperatureto cool to room temperature
  3. filtrationbefore filtering
  4. washThe off white solid was washed with additional benzene (10 mL)
  5. customused without further purification

Quellen und Nachweise

ORD-Eintrag
ord-efc27e70662e4cee8cae76e17e6d8d75
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776869B2

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