p-Fluoronitrobenzene → 1-Isopropyl-4-(4-nitrophenyl)piperazine

To a vial was added 4-fluoronitrobenzene (1.41 g, 1.06 mL, 0.01 mol), N,N-diisopropylethylamine (1.92 mL, 0.011 mmol), isopropylpiperazine (1.41 g, 0.011 mmol), and N,N-dimethylformamide (10 mL). Mixture was heated at 100° C. for 48 h in a sealed tube. The reaction mixture was cooled to room temperature and concentrated. The residue was purified via silica gel column chromatography (gradient elution with 0 to 10% methanol in dichloromethane) to afford 1-isopropyl-4-(4-nitrophenyl)piperazine.

1. temperatureThe reaction mixture was cooled to room temperature
2. concentrationconcentrated
3. customThe residue was purified via silica gel column chromatography (gradient elution with 0 to 10% methanol in dichloromethane)

ORD-Eintrag

ord-351454bab76545c29ab41fad7132488b

Quelldatensatz

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07776869B2