Oxalyl chloride → 2-Iodo-5-nitrobenzoyl chloride

HRID 503686

Reaktionsgleichung

Reaktionsgleichung von HRID 503686
[I:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:17])=O>C(Cl)Cl.CN(C=O)C>[I:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([Cl:17])=[O:5]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 38487452-Iodo-5-nitrobenzoic acid

Produkt 1

HCID 207923042-Iodo-5-nitrobenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

29.30 g (100 mmol) of 2-iodo-5-nitrobenzoic acid are suspended in a mixture of 200 ml of DCM and 1 ml of DMF as solvent. 19.04 g (150 mmol, 1.5 equivalents) of oxalyl chloride are slowly added dropwise at room temperature. The mixture is then stirred at room temperature for two hours and at 30° C. for 30 min. This is followed by evaporation in a rotary evaporator, and the resulting crude product is employed in the following stage.

Aufarbeitung

  1. customThis is followed by evaporation in a rotary evaporator

Quellen und Nachweise

ORD-Eintrag
ord-73987f37de7d4c319c46a86cbe7b8ac3
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776922B2

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