2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid → 2-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-2-methyl-propionic acid methyl ester

HRID 505041

Reaktionsgleichung

Reaktionsgleichung von HRID 505041
[CH3:1][O:2][C:3](=[O:15])[C:4]([CH3:14])([N:6]1[CH:10]=[C:9]([N+:11]([O-])=O)[N:8]=[CH:7]1)[CH3:5].[F:16][C:17]1[CH:18]=[C:19]2[C:24](=[C:25]([F:27])[CH:26]=1)[CH2:23][CH:22]([NH:28][CH:29]([CH2:33][CH2:34][CH3:35])[C:30](O)=[O:31])[CH2:21][CH2:20]2>>[CH3:1][O:2][C:3](=[O:15])[C:4]([N:6]1[CH:10]=[C:9]([NH:11][C:30](=[O:31])[CH:29]([NH:28][CH:22]2[CH2:21][CH2:20][C:19]3[C:24](=[C:25]([F:27])[CH:26]=[C:17]([F:16])[CH:18]=3)[CH2:23]2)[CH2:33][CH2:34][CH3:35])[N:8]=[CH:7]1)([CH3:14])[CH3:5]

Komponenten

3

Edukt 2

HCID 211128022-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acidHCID 67164903methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate

Produkt 1

HCID 117050412-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-2-methyl-propionic acid methyl ester

Versuchsvorschrift

2-Methyl-2-(4-nitro-imidazol-1-yl)-propionic acid methyl ester was reduced and coupled with 2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid to afford the title compound; MS 449.3 m/z (M+1).

Quellen und Nachweise

ORD-Eintrag
ord-f0a91a09417249f38e23402aa6407ade
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781435B2

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