Water → 6-Methoxy-5-methyl-2-nitro-3-pyridinamine

HRID 505381Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 505381
[CH3:1][O:2][C:3]1[N:8]=[C:7]([N+:9]([O-:11])=[O:10])[C:6]([NH:12]C(=O)C)=[CH:5][C:4]=1[CH3:16].[OH-].[Na+].O>CO>[CH3:1][O:2][C:3]1[N:8]=[C:7]([N+:9]([O-:11])=[O:10])[C:6]([NH2:12])=[CH:5][C:4]=1[CH3:16]

Komponenten

5

Edukt 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 59429836N-(6-methoxy-5-methyl-2-nitro-3-pyridinyl)acetamide

Produkt 1

HCID 594298446-Methoxy-5-methyl-2-nitro-3-pyridinamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The crude product (1.93 g) of N-(6-methoxy-5-methyl-2-nitro-3-pyridinyl) acetamide was dissolved in methanol (36 ml), 5N sodium hydroxide solution (6 ml) was added, and the reaction mixture was stirred for 15 minutes at room temperature. After water was added to the reaction solution, it was extracted with ethyl acetate and dried over magnesium sulfate, and the solvent was evaporated, thereby yielding the title compound (1.06 g, 5.79 mmol) as a yellow solid.

Aufarbeitung

  1. extractionwas extracted with ethyl acetate
  2. dry with materialdried over magnesium sulfate
  3. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-7e8cb2b8bc3f4da4a4c933dcf9bf1f6b
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781452B2

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