Water → 3-(4-Methyl-1H-imidazol-1-YL)-5-(trifluoromethyl)benzonitrile

HRID 505920Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 505920
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[H-].[Na+].F[C:10]1[CH:11]=[C:12]([CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1)[C:13]#[N:14].O>CN1CCCC1=O>[CH3:1][C:2]1[N:3]=[CH:4][N:5]([C:10]2[CH:17]=[C:16]([C:18]([F:19])([F:21])[F:20])[CH:15]=[C:12]([CH:11]=2)[C:13]#[N:14])[CH:6]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 24758Sodium hydrideHCID 5190373-Fluoro-5-(trifluoromethyl)benzonitrileHCID 178418800HCID 178418800, Verbindung

Produkt 1

HCID 469003933-(4-Methyl-1H-imidazol-1-YL)-5-(trifluoromethyl)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel3×

Reaktionsbedingungen

Temperatur
22.5 °C

Versuchsvorschrift

A solution of 4-methyl-1H-imidazole (1.98 g, 24.11 mmol) in N-methylpyrrolidinone (NMP) (18 mL) is added to a solution of sodium hydride (0.82 g, 60%, 20.5 mmol) in NMP (18 mL) at 20-25° C. under an atmosphere of nitrogen. The mixture is stirred for 1 hour, before a solution of 3-fluoro-5-trifluoromethyl benzonitrile (XXI) (3.2 g, 16.4 mmol) in NMP (8 mL) is added. The reaction mixture is stirred for 2 hours at 20-25° C. and then water (120 mL) is added within 20 minutes and the resulting suspension is stirred for 16 hours.

Aufarbeitung

  1. additionis added
  2. stirringthe resulting suspension is stirred for 16 hours

Quellen und Nachweise

ORD-Eintrag
ord-8b3e26381594479c995e7b0e340e0bbd
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781597B2

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