Iodine → HCID 178510339, Verbindung

HRID 506172Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506172
[OH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][CH:3]=1.[I:10]I.[OH-].[Na+]>O>[OH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][C:3]=1[I:10]

Komponenten

5

Edukt 3

HCID 807IodineHCID 14798Sodium HydroxideHCID 178510337HCID 178510337, Verbindung

Produkt 1

HCID 178510339HCID 178510339, VerbindungAusbeute 61,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

A mixture of 4-hydroxynicotinonitrile (45.7 g, 381 mmol), iodine (96.6 g, 381 mmol) and NaOH (19.8 g, 825 mmol) in water (600 mL) was heated at 85° C. overnight, cooled to r.t. and diluted with water. The precipitate was collected by filtration and washed with water to give 57.5 g (61%) of 4-hydroxy-5-iodonicotinonitrile as a tan solid. Mp>245° C.

Aufarbeitung

  1. temperaturecooled to r.t.
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-a88d4654205b49ecac2b716b56ed3020
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781591B2

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