HCID 13292919, Verbindung → HCID 178452909, Verbindung

HRID 506587Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506587
[C:1]1([C:7]2[NH:16][C:10]3=[N:11][CH:12]=[C:13]([NH2:15])[CH:14]=[C:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:18]([O:20][CH:21]([CH:23]=[CH2:24])[CH3:22])=[O:19]>N1C=CC=CC=1.ClCCl.O>[CH3:22][CH:21]([O:20][C:18](=[O:19])[NH:15][C:13]1[CH:14]=[C:9]2[N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[NH:16][C:10]2=[N:11][CH:12]=1)[CH:23]=[CH2:24]

Komponenten

6

Edukt 2

HCID 13292919HCID 13292919, VerbindungHCID 178508009HCID 178508009, Verbindung

Produkt 1

HCID 178452909HCID 178452909, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 1049PyridineLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

80 mg 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine (0.38 mmol,) in 3 ml dry pyridine were treated with a solution of 3-buten-2-yl chloroformate in dichloromethane. The mixture was stirred at room temperature over night, diluted with 1 ml water and stirred for another hr. The solvents were evaporated and the residue was dispersed in water with sonication, filtered, and the filter residue washed thoroughly with water and ether.

Aufarbeitung

  1. stirringstirred for another hr
  2. customThe solvents were evaporated
  3. additionthe residue was dispersed in water with sonication
  4. filtrationfiltered
  5. washthe filter residue washed thoroughly with water and ether

Quellen und Nachweise

ORD-Eintrag
ord-fc08b83e49d7436fb938071f3c630d09
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786113B2

Notizen zur Reaktion

Wird geladen…