Water → HCID 178447164, Verbindung

HRID 506588Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506588
[CH3:1][CH:2]([OH:6])[CH:3]=[CH:4][CH3:5].[C:7](N1C=CN=C1)(N1C=CN=C1)=[O:8].[C:19]1([C:25]2[NH:34][C:28]3=[N:29][CH:30]=[C:31]([NH2:33])[CH:32]=[C:27]3[N:26]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>ClCCl.CN1CCCC1=O>[CH3:1][CH:2]([O:6][C:7](=[O:8])[NH:33][C:31]1[CH:32]=[C:27]2[N:26]=[C:25]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[NH:34][C:28]2=[N:29][CH:30]=1)/[CH:3]=[CH:4]/[CH3:5]

Komponenten

7

Edukt 4

HCID 962WaterHCID 15289(+-)-3-Penten-2-olHCID 682631,1'-CarbonyldiimidazoleHCID 178508009HCID 178508009, Verbindung

Produkt 1

HCID 178447164HCID 178447164, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

32 mg 3-penten-2-ol (0.38 mmol,) in 1 ml dry dichloromethane were treated at 0° C. with 62 mg 1,1′-carbonyl-diimidazole. The mixture was stirred at 0° C. for 2 hrs. 80 mg 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine (0.38 mmol,) in 0.5 ml N-methylpyrrolidone (NMP) were added and the mixture stirred over night at room temperature. 1 ml water was added, the precipitate filtered, and the filter residue washed thoroughly with water and ether and further purified by chromatography.

Aufarbeitung

  1. stirringthe mixture stirred over night at room temperature
  2. filtrationthe precipitate filtered
  3. washthe filter residue washed thoroughly with water and ether
  4. customfurther purified by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-41505af1f0fc4283913024858fe5251c
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786113B2

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