3,4-Difluorobenzaldehyde → HCID 178526788, Verbindung

HRID 506600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 506600
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[F:21])[CH:16]=O>[N+](C1C=CC=CC=1)([O-])=O>[F:12][C:13]1[CH:14]=[C:15]([C:16]2[NH:1][C:2]3=[N:3][CH:4]=[C:5]([N+:9]([O-:11])=[O:10])[CH:6]=[C:7]3[N:8]=2)[CH:18]=[CH:19][C:20]=1[F:21]

Komponenten

4

Edukt 2

HCID 5880883,4-DifluorobenzaldehydeHCID 34801515-Nitropyridine-2,3-diamine

Produkt 1

HCID 178526788HCID 178526788, VerbindungAusbeute 27,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7416NitrobenzeneLösungsmittel

Versuchsvorschrift

1.00 g 2,3-diamino-5-nitro-pyridine and 0.95 g 3,4-difluorobenzaldehyde were stirred in 60 ml nitrobenzene at 160° C. for 26 hrs. The solvent was removed under vacuum and the residue dissolved in 40 ml pyridine at 60° C. The solution was cooled in an ice bath. Precipitated product was isolated by filtration and dried to yield 0.5 g of the title product.

Aufarbeitung

  1. customThe solvent was removed under vacuum
  2. dissolutionthe residue dissolved in 40 ml pyridine at 60° C
  3. temperatureThe solution was cooled in an ice bath
  4. customPrecipitated product was isolated by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-99788fbfa8dd4e889b5ae55cc64a8b39
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786113B2

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