Bromine → N-[4-(2-BROMOACETYL)-3-FLUOROPHENYL]acetamide

HRID 507407Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 507407
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=1[F:14])(=[O:3])[CH3:2].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=1[F:14])=[O:3]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 14621109N-(4-Acetyl-3-fluorophenyl)acetamide

Produkt 1

HCID 86346474N-[4-(2-BROMOACETYL)-3-FLUOROPHENYL]acetamideAusbeute 82,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

N-(4-Acetyl-3-fluoro-phenyl)-acetamide (10.2 g, 51.2 mmol) is dissolved in 50 mL chloroform. At room temperature bromine (1.98 mL, 38.4 mmol) is added drop wise. The reaction mixture is stirred at room temperature for 1.5 hours. Subsequently the precipitated product is filtered off, washed first with chloroform and then with ethyl acetate to yield N-[4-(2-bromo-acetyl)-3-fluoro-phenyl]-acetamide (8.7 g, 43%); LCIMS at 254 nm; [M+H] 275; Rt 2.918 min)

Aufarbeitung

  1. filtrationSubsequently the precipitated product is filtered off
  2. washwashed first with chloroform

Quellen und Nachweise

ORD-Eintrag
ord-36ad943755504f6d9a194d0e76d4286b
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786155B2

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