N-(4-bromo-2-fluorophenyl)acetamide → N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N-(4-bromo-2-fluorophenyl)acetamide	HCID 67593	—
Edukt	(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid	HCID 10987806	—
Produkt	N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide	HCID 23509628	—

Reaktionsschritte

Prepared according to procedure B from 4′-bromo-2′-fluoroacetanilide and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. Off white solid, mp 245-247° C. 1H-NMR (DMSO-d6) δ 10.3 (s, 1H), 9.79 (s, 1H), 7.95 (t, 1H, J=8.4 Hz), 7.56-7.63 (m, 3H), 7.47 (dd, 1H, J=1.64, 8.47 Hz), 6.95(d, 1H, J=8.9 Hz), 2.1 (s, 3H), 1.67 (s, 6H); MS+APCI [M+H]+m/z 329. Anal. Calc. For C18H17N2 FO3; C, 65.85; H, 5.22; N, 8.53. Found: C, 65.46; H, 5.24; N, 8.12.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06713478B2
Quelldatensatz	uspto-grants-2004_03
ORD ID	ord-d24c2822817d4911bca185e9654cd3a6
Quellennotiz	uspto-grants-2004_03