Hydrochloric Acid → [4-(Methylamino)phenyl]acetic acid
Reaktionsgleichung
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12]C)=[O:11])=[CH:5][CH:4]=1.[OH-].[Li+].Cl>O1CCCC1>[CH3:1][NH:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:7][CH:8]=1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Methyl 2-(4-(methylamino)phenyl)acetate (721 mg. 4.0 mmol) was dissolved in tetrahydrofuran (10 mL) and treated with a 1 M aqueous solution of lithium hydroxide (4.4 mmol). After 3 hours, the mixture was acidified with 1 N aqueous hydrochloric acid and concentrated to remove tetrahydrofuran. The aqueous phase was extracted with dichloromethane (2×20 mL) and the organic layer was dried and concentrated to give 2-(4-(methylamino)phenyl)acetic acid (309 mg, 1.87 mmol).
Aufarbeitung
- concentrationconcentrated
- customto remove tetrahydrofuran
- extractionThe aqueous phase was extracted with dichloromethane (2×20 mL)
- customthe organic layer was dried
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-e8d93139095f4edeba40ffc9ad2da402
- Quelldatensatz
- uspto-grants-2010_08
- Patentnummer
- US07786171B2
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