4-((Trifluoromethyl)thio)aniline → 2-[4-(dimethylamino)phenyl]-N-{4-[(trifluoromethyl)thio]phenyl}acetamide

HRID 507501

Reaktionsgleichung

Reaktionsgleichung von HRID 507501
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=O)=[CH:5][CH:4]=1.[F:14][C:15]([F:25])([F:24])[S:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>>[CH3:13][N:2]([CH3:1])[C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([NH:21][C:20]2[CH:22]=[CH:23][C:17]([S:16][C:15]([F:25])([F:14])[F:24])=[CH:18][CH:19]=2)=[O:12])=[CH:7][CH:8]=1

Komponenten

3

Edukt 2

HCID 1230544-((Trifluoromethyl)thio)anilineHCID 1522034-N,N-dimethylaminophenylacetic acid

Produkt 1

HCID 442431152-[4-(dimethylamino)phenyl]-N-{4-[(trifluoromethyl)thio]phenyl}acetamide

Versuchsvorschrift

The product was prepared from 2-(4-(dimethylamino)phenyl)acetic acid (23 mg) and 4-trifluoromethylthioaniline (28 mg) according to Method C: 1H NMR (300 MHz, CDCl3) δ ppm 2.98 (s, 6 H), 3.66 (s, 2 H), 6.72-6.78 (m, 2 H), 7.14-7.19 (m, 2 H), 7.19 (s, 1 H), 7.43-7.51 (m, 2 H), 7.52-7.57 (m, 2 H); MS (ESI-pos) m/z 355.0 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-f7b001fe97a5435f810370dd53f80a26
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786171B2

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