Water → (2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

HRID 507786

Reaktionsgleichung

Reaktionsgleichung von HRID 507786
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH3:10])[CH:9]=1)[CH:5]=O.C1C=CC([CH:17]([NH2:20])CO)=CC=1.[OH2:21].[C:22]1([CH3:28])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:27]1([C@@H:22]([CH:28]=[CH:5][C:4]2[CH:3]=[C:2]([CH3:1])[CH:9]=[C:8]([CH3:10])[CH:7]=2)[CH2:23][OH:21])[CH:26]=[CH:25][CH:24]=[N:20][CH:17]=1

Komponenten

5

Edukt 4

HCID 962WaterHCID 1140TolueneHCID 34225Benzaldehyde, 3,5-dimethyl-HCID 924662-Amino-2-phenylethanol

Produkt 1

HCID 68464252(2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

Versuchsvorschrift

A solution of 3,5-dimethylbenzaldehyde (30.0 g) and (R)-phenylglycinol (30.7 g) in toluene (200 ml) was refluxed for 3 hours with removing water. The reaction solution was concentrated to give the title compound (59.7 g) having the following physical data.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-4f181c044fb94d2fad5acf4989f8d97a
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786161B2

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