2-Amino-5-chloropyridine → 3-(5-Chloropyrid-2-yl)carbamoylpyrazine-2-carboxylic acid

HRID 507801

Reaktionsgleichung

Reaktionsgleichung von HRID 507801
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[N:9]1[CH:14]=[CH:13][N:12]=[C:11]2[C:15]([O:17][C:18](=[O:19])[C:10]=12)=[O:16]>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15]([C:11]2[C:10]([C:18]([OH:19])=[O:17])=[N:9][CH:14]=[CH:13][N:12]=2)=[O:16])=[N:3][CH:4]=1

Komponenten

3

Edukt 2

HCID 661742-Amino-5-chloropyridineHCID 78482Furo(3,4-b)pyrazine-5,7-dione

Produkt 1

HCID 32808183-(5-Chloropyrid-2-yl)carbamoylpyrazine-2-carboxylic acidAusbeute 85 %

Versuchsvorschrift

The addition of 2-amino-5-chloropyridine to pyrazine 2,3-dicarboxylic acid anhydride (II) in a lot wise manner at room temperature in a molar ratio of 1.05:1 surprisingly accelerates the reaction to completion in resulting the product, 3-(5-chloropyrid-2-yl)carbamoyl-pyrazine-2-carboxylic acid (III) having high purity (>99%) with a good yield of 85 to 90% when compared with the prior art processes.

Aufarbeitung

  1. customthe reaction to completion

Quellen und Nachweise

ORD-Eintrag
ord-f02e56f6fbad4c4a87ecdbf8dca27859
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07786304B2

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