Sodium borohydride → HCID 22736932, Verbindung

HRID 50855Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 50855
[BH4-].[Na+].[OH:3][C:4]1([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)[CH2:9][CH2:8][N:7]([CH2:10][C:11]([C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]3)=[O:12])[CH2:6][CH2:5]1>C(O)C>[OH:12][CH:11]([C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]2)[CH2:10][N:7]1[CH2:8][CH2:9][C:4]([OH:3])([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)[CH2:5][CH2:6]1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 227369406-{[4-Hydroxy-4-(3-methoxyphenyl)-1-piperidinyl]acetyl}-3,4-dihydroquinolin-2(1h)-one

Produkt 1

HCID 22736932HCID 22736932, VerbindungAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

To a stirred solution of sodium borohydride (1.15 g, 30.3 mmol) in ethanol (100 ml) was added suspension of 6-{[4-Hydroxy-4-(3-methoxyphenyl)-1-piperidinyl]acetyl}-3,4-dihydroquinolin-2(1H)-one (5.98 g, 15.2 mmol) in ethanol (40 ml) at 0° C. and the reaction mixture was stirred at room temperature overnight. The precipitate was filtered and added to methanol (20 ml). The precipitate was collected by filtration to afford the title compound (4.13 g, 69%) as a white solid.

Aufarbeitung

  1. filtrationThe precipitate was filtered
  2. additionadded to methanol (20 ml)
  3. filtrationThe precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-de7cfd67a4e444bfa6aef484216011e4
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713490B2

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