Hydrazine hydrate (1:1) → 2-(4-Morpholinyl)acetohydrazide

HRID 508681

Reaktionsgleichung

Reaktionsgleichung von HRID 508681
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]C)=O)[CH2:3][CH2:2]1.O.[NH2:13][NH2:14]>C(O)C>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([NH:13][NH2:14])=[O:10])[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 1268178Methyl Morpholinoacetate

Produkt 1

HCID 3516352-(4-Morpholinyl)acetohydrazideAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

In a 25 mL, 3-neck round-bottom flask, methyl 2-morpholinoacetate (0.25 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Hydrazine hydrate (0.087 g, 1.1 eq.) was introduced dropwise at RT and the reaction mixture was refluxed at 95° C. for 20 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude 2-morpholinoacetohydrazide (0.23 g) which was used without further purification in the following step.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg)

Quellen und Nachweise

ORD-Eintrag
ord-3b0a93b7c5fc45fb972dc6e5c9848663
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096543B2

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