4-(Benzylamino)-1-methylcyclohexanol → Trans-4-amino-1-methyl-cyclohexanol

HRID 509292

Reaktionsgleichung

Reaktionsgleichung von HRID 509292
C([NH:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:16])([OH:15])[CH2:11][CH2:10]1)C1C=CC=CC=1>CCO.[Pd]>[NH2:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:16])([OH:15])[CH2:11][CH2:10]1

Komponenten

4

Edukt 1

HCID 674652054-(Benzylamino)-1-methylcyclohexanol

Produkt 1

HCID 18331273Trans-4-amino-1-methyl-cyclohexanolAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

4-(Benzylamino)-1-methylcyclohexanol (335 mg, 1.53 mmol) was dissolved in EtOH (7.95 ml), followed by addition of Pd (10 wt % on activated carbon, 35 mg), and then the resulting liquid was stirred at room temperature under hydrogen stream for 31 hours. The resulting reaction liquid was filtered, concentrated under reduced pressure, and dried under vacuum, to obtain 164 mg of white solid (83%).

Aufarbeitung

  1. customThe resulting reaction liquid
  2. filtrationwas filtered
  3. concentrationconcentrated under reduced pressure
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-791d899581944fa1a13752746fd44160
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096571B2

Verknüpfte Notizen

Wird geladen…