Maleic Anhydride → (Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid

HRID 509570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 509570
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH:11]N)=[O:10])[CH:6]=[CH:5][N:4]=1.[O:13]1[C:17](=[O:18])[CH:16]=[CH:15][C:14]1=[O:19]>C1COCC1>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH:11][C:17](=[O:18])/[CH:16]=[CH:15]\[C:14]([OH:19])=[O:13])=[O:10])[CH:6]=[CH:5][N:4]=1

Komponenten

4

Edukt 2

HCID 7923Maleic AnhydrideHCID 3225512-Methoxyisonicotinohydrazide

Produkt 1

HCID 67958827(Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of compound 8 (167 mg, 1.0 mmol) in 10 mL of THF was added furan-2,5-dione (110 mg, 1.1 mmol). The mixture was stirred at ambient temperature for 2 hours. After removal of the solvent, the residue was diluted with 10 mL of dichloromethane. The solid was collected by filtration to give (Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid 9 as a solid.

Aufarbeitung

  1. customAfter removal of the solvent
  2. additionthe residue was diluted with 10 mL of dichloromethane
  3. filtrationThe solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-1ea406fcc7f647e78ff09f09a921dd3d
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096587B2

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