N-(5-Carbamoylpyrimidin-4-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide → HCID 178517573, Verbindung

HRID 510103Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 510103
[C:1]([C:4]1[C:5]([NH:10][C:11]([C:13]2[C:21]3[C:16](=[N:17][CH:18]=[CH:19][CH:20]=3)[N:15]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[F:29])[N:14]=2)=O)=[N:6][CH:7]=[N:8][CH:9]=1)(=[O:3])[NH2:2]>CN(C)C(=O)C>[F:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[CH2:22][N:15]1[C:16]2=[N:17][CH:18]=[CH:19][CH:20]=[C:21]2[C:13]([C:11]2[N:2]=[C:1]([OH:3])[C:4]3[C:5]([N:10]=2)=[N:6][CH:7]=[N:8][CH:9]=3)=[N:14]1

Komponenten

3

Edukt 1

HCID 66614289N-(5-Carbamoylpyrimidin-4-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide

Produkt 1

HCID 178517573HCID 178517573, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Reaktionsbedingungen

Temperatur
220 °C

Versuchsvorschrift

246 mg (0.629 mmol) of the compound from example 48A were initially charged in N,N-dimethylacetamide (22 ml) and stirred in a microwave at 220° C. for 30 min. The reaction mixture was poured onto ice-water and filtered. The filter residue was washed with water and dried under high vacuum at 50° C. overnight. This gave 142 mg (57% of theory) of the title compound in solid form.

Aufarbeitung

  1. additionThe reaction mixture was poured onto ice-water
  2. filtrationfiltered
  3. washThe filter residue was washed with water
  4. customdried under high vacuum at 50° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-3bf1eab3db4f458bbe60fcd9cf775f06
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096592B2

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