Diethyl Carbonate → 3-Fluorothioanisole

Temperatur

100 °C

To a solution of 3-fluorothiophenol (4.73 g, 37.0 mmol) in diethyl carbonate (11 mL, 129 mmol) was added K2CO3 (7.67 g, 55.5 mmol) and 18-crown-6 ether (100 mg, 0.37 mmol). The reaction mixture was refluxed at 100° C. for 12 h. The reaction mixture was cooled to 20° C. then quenched by addition of H2O and extracted with Et2O. The combine organic solution was washed with H2O and brine, dried over MgSO4.to give 1-fluoro-3-(methylsulfanyl)benzene (5.10 g, 97%) as a colorless oil.

1. temperatureThe reaction mixture was cooled to 20° C.
2. customthen quenched by addition of H2O
3. extractionextracted with Et2O
4. washThe combine organic solution was washed with H2O and brine
5. dry with materialdried over MgSO4

ORD-Eintrag

ord-0d6e430934f24b54a20264e763a83e3e

Quelldatensatz

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06713471B1