Dimethylformamide → 2-Fluoro-3-(trifluoromethyl)benzoyl chloride

HRID 510232Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 510232
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13]C=1C(O)=O.CN(C=O)C>C(Cl)Cl>[F:7][C:8]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][C:1]=1[C:2]([Cl:4])=[O:3]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 5180022-Fluoro-3-(trifluoromethyl)benzoic acid

Produkt 1

HCID 27375592-Fluoro-3-(trifluoromethyl)benzoyl chlorideAusbeute 99,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Oxalyl chloride (0.488 mL, 5.76 mmol) was added to a suspension of 2-fluoro-3-(trifluoromethyl)benzoic acid (1.00 g, 4.81 mmol) in DCM (10 mL) containing catalytic DMF. The reaction was stirred at room temperature for 90 minutes and solvents were removed in vacuo to afford the desired compound (1.08 g, 99%). The product was used without additional purification.

Aufarbeitung

  1. customsolvents were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-050408838199402b9bf1d1e4faa20359
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096596B2

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