4-Methoxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one → 7-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one

HRID 511439Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 511439
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:4]=1[CH2:5][N:6]([CH3:16])[C:7]2=[O:15]>CO.CCOC(C)=O.[Pd]>[NH2:12][C:9]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[C:4]2[C:8]=1[C:7](=[O:15])[N:6]([CH3:16])[CH2:5]2

Komponenten

5

Edukt 1

HCID 598491794-Methoxy-2-methyl-7-nitro-2,3-dihydro-isoindol-1-one

Produkt 1

HCID 672539417-Amino-4-methoxy-2-methyl-2,3-dihydroisoindol-1-one

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Pd/C (7.67 mg, 0.0720 mmol) was added to a solution of 4-methoxy-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one in MeOH (2 mL) and EtOAc (2 mL) and the mixture was hydrogenated at stp overnight. The solution was filtered and the title compound was not further purified. MS (ES+): m/z 193.14 (100) [MH+]; HPLC: tR=0.65 min (UPLC, analytical).

Aufarbeitung

  1. filtrationThe solution was filtered

Quellen und Nachweise

ORD-Eintrag
ord-f7117982141144bc9151866a48213d0d
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096624B2

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