Cesium carbonate → 2-broMo-3-(difluoroMethoxy)pyridine

HRID 512073Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 512073
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[C:10]([F:15])([F:14])C([O-])=O.[Na+].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C.O>[Br:1][C:2]1[C:7]([O:8][CH:10]([F:15])[F:14])=[CH:6][CH:5]=[CH:4][N:3]=1

Komponenten

6

Edukt 3

HCID 10796Cesium carbonateHCID 230702-Bromo-3-pyridinolHCID 2734985Sodium chlorodifluoroacetate

Produkt 1

HCID 580424482-broMo-3-(difluoroMethoxy)pyridineAusbeute 35,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of 2-bromo-3-pyridinol (1.26 g, 7.23 mmol) in DMF (35 mL) and water (5 mL) was added sodium chlorodifluoroacetate (2.93 g, 18.1 mmol) followed by cesium carbonate (4.71 g, 14.5 mmol). The reaction was heated to 100° C. for 36 hours before partitioning between EtOAc and water. The organic layer was collected, dried over magnesium sulfate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with EtOAc:heptane 1:3 to afford the title compound as a colourless oil (570 mg, 35%).

Aufarbeitung

  1. custombefore partitioning between EtOAc and water
  2. customThe organic layer was collected
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified
  6. washeluting with EtOAc:heptane 1:3

Quellen und Nachweise

ORD-Eintrag
ord-2e4d28557e22415e9b773334eea93f67
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102621B2

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