2-Amino-4-chlorophenol → HCID 178527795, Verbindung

HRID 512442Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 512442
O(CC)[C:2]([S-])=[S:3].[K+].[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([NH2:16])[CH:10]=1>C(O)C>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]2[O:15][C:2]([SH:3])=[N:16][C:11]=2[CH:10]=1

Komponenten

4

Edukt 2

HCID 72652-Amino-4-chlorophenolHCID 2735045Potassium ethylxanthate

Produkt 1

HCID 178527795HCID 178527795, VerbindungAusbeute 99,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of potassium ethyl xanthate (13.4 g, 84.0 mmol) and 4-chloro-2-aminophenol (10 g, 69.6 mmol) was dissolved in absolute ethanol (200 mL). The mixture was stirred under reflux overnight. After cooling, the solvent was evaporated under reduced pressure, the residue was dissolved in water (200 mL) and treated with HOAc to adjust pH to 5. A solid formed, which was filtered and dried to afford 5-chloro-2-mercaptobenzoxazole (12.8 g, yield 99.1%).

Aufarbeitung

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. customthe solvent was evaporated under reduced pressure
  4. dissolutionthe residue was dissolved in water (200 mL)
  5. additiontreated with HOAc
  6. customA solid formed
  7. filtrationwhich was filtered
  8. customdried

Quellen und Nachweise

ORD-Eintrag
ord-333a50b1313d4f728f291bcb92d393b9
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102636B2

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