Pyridine → 1-Butoxy-4-chloro-4,5,5,5-tetrafluoropent-1-en-3-one

HRID 512480Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 512480
[Cl:1][C:2]([F:10])([C:6]([F:9])([F:8])[F:7])[C:3](Cl)=[O:4].N1C=CC=CC=1.[CH:17]([O:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH2:18]>ClCCl>[CH2:20]([O:19][CH:17]=[CH:18][C:3](=[O:4])[C:2]([Cl:1])([F:10])[C:6]([F:9])([F:8])[F:7])[CH2:21][CH2:22][CH3:23]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 8108Butyl vinyl etherHCID 27824982-Chloro-2,3,3,3-tetrafluoropropanoyl chloride

Produkt 1

HCID 866240961-Butoxy-4-chloro-4,5,5,5-tetrafluoropent-1-en-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

With stirring and at 0° C., 9.59 g (48.2 mmol) of 2-chlorotetrafluoropropionyl chloride were added dropwise to a mixture of 4.19 g (50.0 mmol) of pyridine and 4.83 g (48.2 mmol) of butyl vinyl ether in 75 ml of dichloromethane. After the addition, stirring was continued at room temperature for another 15 h. The mixture was then washed with 1N hydrochloric acid and 2×100 ml of water, and the organic phase was separated off, dried and concentrated. This gave 6.33 g (50% of theory) of a brown oil.

Aufarbeitung

  1. additionAfter the addition
  2. stirringstirring
  3. washThe mixture was then washed with 1N hydrochloric acid and 2×100 ml of water
  4. customthe organic phase was separated off
  5. customdried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4ad6f0766f9e4ce5bc41e5dca8b88e96
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102623B2

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