2-Amino-2-cyanoacetamide → 5-Amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

HRID 512547

Reaktionsgleichung

Reaktionsgleichung von HRID 512547
[N:1]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]=[CH:6][CH:5]=1)=[C:2]=[S:3].[NH2:14][CH:15]([C:19]#[N:20])[C:16]([NH2:18])=[O:17]>CCOC(C)=O>[NH2:20][C:19]1[S:3][C:2]([NH:1][C:4]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]=[CH:6][CH:5]=2)=[N:14][C:15]=1[C:16]([NH2:18])=[O:17]

Komponenten

4

Edukt 2

HCID 983412-Amino-2-cyanoacetamideHCID 114993404-Isothiocyanatoquinoline

Produkt 1

HCID 867033825-Amino-2-(quinolin-4-ylamino)thiazole-4-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 4-isothiocyanatoquinoline (0.3 g, 1.6 mmol) and 2-amino-cyanoacetamide (0.26g, 2.68 mmol) in EtOAc (20 mL) was refluxed for 90 min. The reaction mixture was concentrated in vacuo, and the resulting solids were collected and washed with EtOAc to give 0.33 g (contained impurities) of the titled compound which was used in the next step without further purification.

Aufarbeitung

  1. temperaturewas refluxed for 90 min
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customthe resulting solids were collected
  4. washwashed with EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-dd0b882fa8f8490fa1dd59d7dfe7fa8d
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09102637B2

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