3-Fluorobenzylamine → HCID 86664548, Verbindung

To a solution of ethyl 4,5,6-trichloronicotinate (200 mg, 0.78 mmol) in AcCN (1.5 mL) was added 3-fluorobenzylamine (0.108 mL, 0.94 mmol) and DIPEA (0.167 mL, 0.94 mmol). The mixture was stirred at room temperature for 5 h them at 50° C. until the reaction is over. The solution was cooled and concentrated, the resulting residue was diluted with water, the solid was then collected by filtration to give ethyl 5,6-dichloro-4-(3-fluorobenzylamino)nicotinate (260 mg).

1. temperatureThe solution was cooled
2. concentrationconcentrated
3. additionthe resulting residue was diluted with water
4. filtrationthe solid was then collected by filtration

ORD-Eintrag

ord-669a8ed46d5f43fa8b43cdf0ee69a91d

Quelldatensatz

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09102625B2