HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
8-Aminoquinoline → 3-(Quinolin-8-ylsulfamoyl)-benzoic acid methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 8-Aminoquinoline | HCID 11359 | — |
| Edukt | Benzoic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 113339 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Produkt | 3-(Quinolin-8-ylsulfamoyl)-benzoic acid methyl ester | HCID 31702993 | 64% |
Reaktionsschritte
In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), methyl 3-chlorosulfonylbenzoate (160 mg, 0.69 mmol) and DMAP (cat.) gave the title compound (150 mg, 64%) after purification by column chromatography with DCM as the eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09102688B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-8dee330c2dd447c49a029927665986ad |
| Quellennotiz | uspto-grants-2015_08 |