Hydrochloric Acid → HCID 178479550, Verbindung

Temperatur

80 °C

Under the nitrogen atmosphere, 10 g of 2-aminomalonamide and 38.4 mg of oxalic acid were added to 200 mL of 2-propanol. After heating to 80° C., 35.4 mL of triethyl orthoformate was added dropwise to the mixture over 5 minutes. Subsequently, the reaction mixture was stirred for 8 hours at 80° C. Color of the reaction liquid was pale yellow when the reaction was completed. Subsequently, after cooling to 53° C., the reaction mixture was added with 10 mL of water followed by 8 mL of conc. hydrochloric acid. After cooling with water, the crystal was collected by filtration and then washed with 40 mL of acetone to give 16 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate as a pale yellow crystal.

1. customColor of the reaction liquid
2. temperatureSubsequently, after cooling to 53° C.
3. filtrationthe crystal was collected by filtration
4. washwashed with 40 mL of acetone

ORD-Eintrag

ord-1747dace88a1407683aaf31260aed32b

Quelldatensatz

uspto-grants-2015_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09108928B2