Methylamine → 6-Chloro-N-methyl-1,3-benzothiazol-2-amine

HRID 514835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 514835
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:12][NH2:13]>C1COCC1.O>[Cl:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:13][CH3:12])[S:3][C:4]=2[CH:10]=1

Komponenten

5

Edukt 2

HCID 6329MethylamineHCID 771762,6-Dichlorobenzothiazole

Produkt 1

HCID 107743586-Chloro-N-methyl-1,3-benzothiazol-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 2,6-dichlorobenzo[d]thiazole (2 g, 10 mmol) in 10 mL THF was added 25% MeNH2 in water (3 mL) dropwise. After the addition complete, the reaction mixture was stirred at room temperature overnight. Filter off the product and washed with methanol. Drying in vacuo to yield 1.5 g of the desired compound. LC-MS: m/z 204.2 (M+H)+

Aufarbeitung

  1. filtrationFilter off the product
  2. washwashed with methanol
  3. customDrying in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0318590f01e946df9d95384d65449ffa
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09108921B2

Notizen zur Reaktion

Wird geladen…