6-Methyl-5-nitropicolinic acid → HCID 82594963, Verbindung

HRID 514845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 514845
[CH3:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N+:11]([O-])=O>CO.[Pd]>[NH2:11][C:3]1[CH:4]=[CH:5][C:6]([C:8]([OH:10])=[O:9])=[N:7][C:2]=1[CH3:1]

Komponenten

4

Edukt 1

HCID 74720376-Methyl-5-nitropicolinic acid

Produkt 1

HCID 82594963HCID 82594963, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 6-methyl-5-nitropicolinic acid (31C, 500 mg, 2.75 mmol) in methanol (10 ml) was added Pd/C (50 mg). The solution was stirred at r.t. under H2 atmosphere for 1 h, when LC-MS showed that s.m. was consumed. Then the mixture was filtered and concentrated to give the crude product which was used to the next step without further purification. LC-MS: m/z 153 (M+H)+

Aufarbeitung

  1. customwas consumed
  2. filtrationThen the mixture was filtered
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0c9589bf60f842e2908f53f4dcf05489
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09108921B2

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