Hydrochloric Acid → HCID 22736374, Verbindung

HRID 51502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 51502
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].Br[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)=[O:9].[ClH:23]>CC(O)C>[ClH:23].[O:16]([C:13]1[CH:12]=[CH:11][C:10]([C:8](=[O:9])[CH2:7][NH:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:15][CH:14]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6385Tert-ButylamineHCID 147976752-Bromo-1-(4-phenoxyphenyl)ethan-1-one

Produkt 1

HCID 22736374HCID 22736374, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Tert-butylamine (15 ml) was added with stirring to a solution of 2-bromo-4′-phenoxyacetophenone (12.7 g, prepared by bromination of 4′-phenoxyacetophenone according to Tetrahedron Letters, 1993, 34, 3177) in propan-2-ol and the mixture heated at 80° C. for 3 hours. The mixture was cooled to 0C and concentrated hydrochloric acid (10 ml) added. The suspension was stirred at ambient temperature for 18 hours and the solid collected by filtration to give 4′-phenoxy-2-(tert-butylamino)acetophenone hydrochloride (3.75 g), m.p. 210-212° C.

Aufarbeitung

  1. additionadded
  2. filtrationthe solid collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-10bcbe4c035a4e2398723ff776cfecad
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713474B2

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