Oxalyl chloride → 3-Methoxy-5-isoxazolecarbonyl chloride

HRID 516442Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 516442
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([C:8]([OH:10])=O)[O:5][N:4]=1.C(Cl)(=O)C([Cl:14])=O>C1COCC1.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:7]=[C:6]([C:8]([Cl:14])=[O:10])[O:5][N:4]=1

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 3277173-Methoxy-1,2-oxazole-5-carboxylic acid

Produkt 1

HCID 121963593-Methoxy-5-isoxazolecarbonyl chlorideAusbeute 88,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3-methoxyisoxazole-5-carboxylic acid (420 mg, 3 mmol) in THF (15 mL) and DMF (5 drop) was added dropwise oxalyl chloride (650 μL, 7 mmol) at 0° C. The mixture was then stirred at room temperature for 3 hours. The solution was concentrated in vacuo to yield the title compound as a light yellow oil (430 mg).

Aufarbeitung

  1. concentrationThe solution was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a8e8020150a84d619f1c2d94e2ab23d5
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09108934B2

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