Diethyl Ether → 7-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 517103

Reaktionsgleichung

Reaktionsgleichung von HRID 517103
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]3)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.O1CCOCC1.C(OCC)C.C(Cl)[Cl:40]>>[ClH:40].[F:27][C:2]([F:1])([F:26])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][NH:15][CH2:16]3)=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

Komponenten

5

Edukt 4

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 70974981tert-Butyl 7-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Produkt 1

HCID 709747087-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Versuchsvorschrift

To a solution of tert-butyl 7-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1.4 g, 3.7 mmol) in DCM (3 was added 4.0M HO in dioxane (4.6 mL, 18.56 mmol) and stirred at rt for 3 h. Diethylether (200 mL) was then added and the mixture was stirred at rt for 30 min and then filtered and washed with diethylether and dried to give the title compound (1.3 grams).

Aufarbeitung

  1. stirringthe mixture was stirred at rt for 30 min
  2. filtrationfiltered
  3. washwashed with diethylether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4cefd45676d74f3f9c689da47a8482fb
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115096B2

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