Water → 4-(2,5-Dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-3-methylbenzonitrile

HRID 517270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 517270
Cl.[NH2:2][CH:3]([C:13]1[C:18](=[O:19])[CH2:17][CH2:16][CH2:15][C:14]=1[NH:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=1)[C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][C:5]=1[CH3:12].[CH2:31](N(CC)CC)C.[OH2:38]>C(#N)C>[O:38]=[C:31]1[NH:2][CH:3]([C:4]2[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][C:5]=2[CH3:12])[C:13]2[C:18](=[O:19])[CH2:17][CH2:16][CH2:15][C:14]=2[N:20]1[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:28])([F:29])[F:30])[CH:22]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 8471TriethylamineHCID 867323404-(Amino(6-oxo-2-(3-(trifluoromethyl)phenylamino)cyclohex-1-enyl)methyl)-3-methylbenzonitrile hydrochloride2×

Produkt 1

HCID 867323954-(2,5-Dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-3-methylbenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A mixture of 4-(amino(6-oxo-2-(3-(trifluoromethyl)phenylamino)cyclohex-1-enyl)methyl)-3-methylbenzonitrile hydrochloride (intermediate 52, 1.06 g, 2.43 mmol), 1,1-carbonyl-diimidazole (495 mg, 3.05 mmol) and triethylamine (685 μL, 4.87 mmol) in acetonitrile (10 mL) is stirred at room temperature over night. Water ist added, and the mixture is extracted with dichloromethane. The phases are separated, and the organic layer is concentrated under reduced pressure. The residue is by purified by preparative HPLC (Waters it) Xbridge™-C18, gradient of acetonitrile in water, 0.1% TFA). Yield: 364 mg; ESI mass spectrum [M+H]+=426; Retention time HPLC: 0.65 min (X012_S01).

Aufarbeitung

  1. extractionthe mixture is extracted with dichloromethane
  2. customThe phases are separated
  3. concentrationthe organic layer is concentrated under reduced pressure
  4. customby purified by preparative HPLC (Waters it) Xbridge™-C18, gradient of acetonitrile in water, 0.1% TFA)
  5. custom0.65 min (X012_S01)

Quellen und Nachweise

ORD-Eintrag
ord-59338dee26114a74b39f340011b6dd70
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115093B2

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