Tetrabutylammonium Fluoride → HCID 22568834, Verbindung

To a solution of [4-(1-ethoxycyclopropyl)-3-tert-butyl-phenoxy]-triisopropyl-silane (Intermediate 108, 600.0 mg, 1.54 mmol) in 3 mL THF at 0° C. was added tetrabutylammonium fluoride (802.8.0 mg, 3.07 mmols; 3.1 mL of a 1 M solution in THF). The solution was stirred at 0° C. for 30 minutes and then quenched by the addition of H2O. The mixture was extracted with EtOAc and the combined organic layers were washed with H2O and saturated aqueous NaCl before being dried (MgSO4) and concentrated under reduced pressure. The title compound (400 mg, 88%) was isolated from the residue by column chromatography (4-10% EtOAc-hexanes) as a colorless solid.

1. customquenched by the addition of H2O
2. extractionThe mixture was extracted with EtOAc
3. washthe combined organic layers were washed with H2O and saturated aqueous NaCl
4. dry with materialbefore being dried (MgSO4)
5. concentrationconcentrated under reduced pressure

ORD-Eintrag

ord-84dd141ab67c4958bd46644aef88a2d2

Quelldatensatz

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06713647B2