Dimethylamine → US9115126, Example 35

HRID 517989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 517989
CS(OCCCOC1C=[CH:14][C:13]([C:16]2C=[C:18]([C:26]#[N:27])[C:19]3[N:23]=[N:22][N:21]([CH3:24])[C:20]=3[CH:25]=2)=[CH:12][C:11]=1[C:28]([F:31])([F:30])[F:29])(=O)=O.[CH:32]([N:35]([CH:38](C)C)[CH2:36]C)(C)C.C[NH:42]C.[CH2:44]1[CH2:48][O:47][CH2:46][CH2:45]1>>[CH3:32][N:35]([CH3:38])[CH2:36][CH2:44][CH2:48][O:47][C:46]1[CH:45]=[CH:14][C:13]([C:16]2[N:42]=[C:18]([C:26]#[N:27])[C:19]3[N:23]=[N:22][N:21]([CH3:24])[C:20]=3[CH:25]=2)=[CH:12][C:11]=1[C:28]([F:29])([F:30])[F:31]

Komponenten

5

Edukt 4

HCID 674DimethylamineHCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 866733533-(4-(4-cyano-1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-2-(trifluoromethyl)phenoxy)propyl methanesulfonate

Produkt 1

HCID 53330392US9115126, Example 35

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 3-(4-(4-cyano-1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-2-(trifluoro-methyl)phenoxy)propyl methanesulfonate (20 mg), diisopropylethylamine (73 μl) and dimethylamine in THF (2M, 1 ml) was heated at 100° C. under microwave conditions for 20 minutes. The mixture was purified by HPLC to give the expected product (6.3 mg).

Aufarbeitung

  1. customThe mixture was purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-f496b8a22efa47968c2c9382b6029aa4
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115126B2

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