Triethylamine → 2-(4-Bromo-2-(trifluoromethyl)phenoxy)ethyl methanesulfonate

HRID 518001Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 518001
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.C(N(CC)CC)C.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>C(Cl)Cl>[CH3:23][S:24]([O:9][CH2:8][CH2:7][O:6][C:5]1[CH:10]=[CH:11][C:2]([Br:1])=[CH:3][C:4]=1[C:12]([F:13])([F:14])[F:15])(=[O:26])=[O:25]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 576575832-(4-Bromo-2-(trifluoromethyl)phenoxy)-ethanol

Produkt 1

HCID 866733562-(4-Bromo-2-(trifluoromethyl)phenoxy)ethyl methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-(4-Bromo-2-(trifluoromethyl)phenoxy)ethanol (17.54 mmol, 5 g) and triethylamine (35.1 mmol, 4.88 ml, 3.55 g) were combined and stirred in DCM (100 ml) at 0° C. methanesulfonyl chloride (26.3 mmol, 2.036 ml, 3.01 g) was added and the reaction allowed to warm to room temperature over 1 hour. The reaction mixture was washed with water, dried over sodium sulfate and concentrated in vacuo to afford 2-(4-bromo-2-(trifluoromethyl)phenoxy)ethyl methanesulfonate. (5.64 g)

Aufarbeitung

  1. additionwas added
  2. washThe reaction mixture was washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a0419f61afaf428695f8db8a1aafd497
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09115126B2

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