Lithium hydroxide, monohydrate → HCID 22736861, Verbindung

HRID 51918

Reaktionsgleichung

Reaktionsgleichung von HRID 51918
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[C:11]([NH:16][C:17]([C:19]1[C:20]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=3)=[N:21][CH:22]=[CH:23][CH:24]=1)=[O:18])[CH:10]=2)=[O:5])C.O.[OH-].[Li+]>O1CCCC1CO.O>[F:34][C:31]([F:32])([F:33])[C:28]1[CH:29]=[CH:30][C:25]([C:20]2[C:19]([C:17]([NH:16][C:11]3[CH:10]=[C:9]4[C:14]([CH:15]=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]4)=[CH:13][CH:12]=3)=[O:18])=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:26][CH:27]=1

Komponenten

4

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 698915467-{[2-(4-Trifluoromethyl-phenyl)-pyridine-3-carbonyl]-amino}-quinoline-3-carboxylic acid ethyl ester

Produkt 1

HCID 22736861HCID 22736861, VerbindungAusbeute 98,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 66577907Tetrahydrofuran-methanol waterLösungsmittel

Versuchsvorschrift

7-{[2-(4-Trifluoromethyl-phenyl)-pyridine-3-carbonyl]-amino}-quinoline-3-carboxylic acid ethyl ester (160 mg, 0.34 mmol) was dissolved in 5 ml of a 3:1:1 mixture of tetrahydrofuran-methanol-water, and lithium hydroxide monohydrate (29 mg, 0.69 mmol) was added. After 2.5 h at room temperature, the volatiles were removed under vacuum and 5 ml of water was added to the mixture, which was brought to pH 4 with 1N HCl. The resulting slurry was filtered to provide 147 mg of the title compound as a yellow solid.

Aufarbeitung

  1. additionwas added
  2. customthe volatiles were removed under vacuum and 5 ml of water
  3. additionwas added to the mixture, which
  4. filtrationThe resulting slurry was filtered

Quellen und Nachweise

ORD-Eintrag
ord-79019a62b59647e790d1a8cf3d4d2932
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06713489B2

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