Triethylamine → 2-(Chloromethyl)pyrimidin-4-amine

HRID 520499Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 520499
Cl.Cl.[Cl:3][CH2:4][C:5](=[NH:7])[NH2:6].Cl[C:9](=[CH2:12])[C:10]#[N:11].C(N(CC)CC)C>C(O)C>[Cl:3][CH2:4][C:5]1[N:6]=[C:10]([NH2:11])[CH:9]=[CH:12][N:7]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 701982-ChloroacrylonitrileHCID 86660238HCID 86660238, Verbindung

Produkt 1

HCID 212988272-(Chloromethyl)pyrimidin-4-amineAusbeute 18 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-chloroacetimidamide dihydrochloride 124 (250.0 g, 1.51 mol), 2-chloroacrylonitrile 125 (171 g, 1.95 mol) and triethylamine (490 g, 4.8 mol) in anhydrous ethanol (600 mL) was heated at reflux for 30 min. The solvent was removed in vacuo and the residue was purified by flash chromatography (dichloromethane:methanol=30:1) to give 126 (39.0 g, 18% yield).

Aufarbeitung

  1. temperatureat reflux for 30 min
  2. customThe solvent was removed in vacuo
  3. customthe residue was purified by flash chromatography (dichloromethane:methanol=30:1)

Quellen und Nachweise

ORD-Eintrag
ord-7e7013c991bb4919967696fcfb8fcfdf
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09326986B2

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