Acetic Anhydride → N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(2-acetoxyethylthio)butyramide

HRID 52052

Reaktionsgleichung

Reaktionsgleichung von HRID 52052
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:28])[CH2:21][CH2:22][CH2:23][S:24][CH2:25][CH2:26][OH:27])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:29](OC(=O)C)(=[O:31])[CH3:30]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:28])[CH2:21][CH2:22][CH2:23][S:24][CH2:25][CH2:26][O:27][C:29](=[O:31])[CH3:30])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 67725591N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(2-hydroxyethylthio)butyramide

Produkt 1

HCID 67725586N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(2-acetoxyethylthio)butyramideAusbeute 80 %

Versuchsvorschrift

Following a procedure similar to that described in Example 2, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-(2-hydroxyethylthio)butyramide (prepared as described in Example 3) and acetic anhydride as starting materials, in relative proportions similar to those used in that Example, the title compound, melting at 36°-40° C., was obtained in an 80% yield.

Quellen und Nachweise

ORD-Eintrag
ord-d9b235dc18d24b6588d5925c474fd755
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616579

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