Acetic Anhydride → N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-3-(2-acetoxyethylthio)propionamide

HRID 52057Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 52057
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:27])[CH2:21][CH2:22][S:23][CH2:24][CH2:25][OH:26])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:28](OC(=O)C)(=[O:30])[CH3:29]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:27])[CH2:21][CH2:22][S:23][CH2:24][CH2:25][O:26][C:28](=[O:30])[CH3:29])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 67725561N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-3-(2-hydroxyethylthio)propionamide

Produkt 1

HCID 67725579N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-3-(2-acetoxyethylthio)propionamideAusbeute 87 %

Versuchsvorschrift

Following a procedure similar to that described in Example 2, but using N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-3-(2-hydroxyethylthio)propionamide (prepared as described in Example 11) and acetic anhydride as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in an 87% yield.

Quellen und Nachweise

ORD-Eintrag
ord-b3ffc11fad484fa4a8bc3e6181654def
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05616579

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